The Gandal Lab
Vlasova, R. M., Iosif, A.-M., Ryan, A. M., Murai, T., Lesh, T. A., Rowland, D. J., Bennett, J., Hogrefe, C. E., Maddock, R. J., Gandal, M. J., Geschwind, D. H., Schumann, C. M., Van de Water, J., Kimberley McAllister, A., Carter, C. S., Styner, M. A., Amaral, D. G., & Bauman, M. D. (2020). Maternal immune activation during pregnancy alters early neurobehavioral development in nonhuman primate offspring. bioRxiv 2020.07.02.185363.
Jeffries, A. R., Leung, S. K., Castanho, I., Moore, K., Davies, J. P., Dempster, E. L., Bray, N. J., O‘Neill, P., Tseng, E., Ahmed, Z., Collier, D., Prabhakar, S., Schalkwyk, L., Gandal, M. J., Hannon, E., & Mill, J. (2020). Full-length transcript sequencing of human and mouse identifies widespread isoform diversity and alternative splicing in the cerebral cortex. bioRxiv 2020.10.14.339200.
Kim, M., Haney, J. R., Zhang, P., Hernandez, L. M., Wang, L.-K., Perez-Cano, L., & Gandal, M. J. (2020). "Network signature of complement component 4 variation in the human brain identifies convergent molecular risk for schizophrenia". bioRxiv 2020.03.03.975722.
Hernandez, L. M., Kim, M., Hernandez, C., Thompson, W., Fan, C. C., Galván, A., Dapretto, M., Bookheimer, S. Y., Fuligni, A., & Gandal, M. (2020). "The genetic etiology of childhood insomnia: Longitudinal gene-brain-behavior associations in the ABCD study." medRxiv, 2020.10.02.20204735.
Mullins, N., Kang, J., Campos, A. I., Coleman, J. R. I., Edwards, A. C., Galfalvy, H., Levey, D. F., Lori, A., Shabalin, A., Starnawska, A., Su, M.-H., Watson, H. J., Adams, M., Awasthi, S., Gandal, M., Hafferty, J. D., Hishimoto, A., Kim, M., Okazaki, S., … Ruderfer, D. M. (2020). Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders and known risk factors. medRxiv, 2020.12.01.20241281.
Mullins, N., Forstner, A. J., Coombes, B., Coleman, J. R. I., Qiao, Z., Als, T. D., Bigdeli, T. B., Børte, S., Bryois, J., Charney, A. W., Drange, O. K., Gandal, M. J., Hagenaars, S. P., Ikeda, M., Kamitaki, N., Kim, M., Krebs, K., Panagiotaropoulou, G., Schilder, B. M., … Andreassen, O. A. (2020). Genome-wide association study of over 40,000 bipolar disorder cases provides novel biological insights. medRxiv, 2020.09.17.20187054.
Watanabe, M., Haney, J. R., Vishlaghi, N., Turcios, F., Buth, J. E., Gu, W., Collier, A. J., Miranda, O. A., Chen, D., Sabri, S., Clark, A. T., Plath, K., Christofk, H. R., Gandal, M. J., & Novitch, B. G. (2019). TGFβ superfamily signaling regulates the state of human stem cell pluripotency and competency to create telencephalic organoids. bioRxiv 2019.12.13.875773.
Dahl, A., Nguyen, K., Cai, N., Gandal, M. J., Flint, J., & Zaitlen, N. (2020). A Robust Method Uncovers Significant Context-Specific Heritability in Diverse Complex Traits. American Journal of Human Genetics, 106(1), 71–91.
Forsyth, J. K., Nachun, D., Gandal, M. J., Geschwind, D. H., Anderson, A. E., Coppola, G., & Bearden, C. E. (2020). Synaptic and Gene Regulatory Mechanisms in Schizophrenia, Autism, and 22q11.2 Copy Number Variant-Mediated Risk for Neuropsychiatric Disorders. Biological Psychiatry, 87(2), 150–163.
Ramaswami, G., Won, H., Gandal, M. J., Haney, J., Wang, J. C., Wong, C. C. Y., Sun, W., Prabhakar, S., Mill, J., & Geschwind, D. H. (2020). Integrative genomics identifies a convergent molecular subtype that links epigenomic with transcriptomic differences in autism. Nature Communications, 11(1), 4873.
Hernandez, L. M., Kim, M., Hoftman, G. D., Haney, J. R., de la Torre-Ubieta, L., Pasaniuc, B., & Gandal, M. J. (2020). Transcriptomic Insight Into the Polygenic Mechanisms Underlying Psychiatric Disorders. Biological Psychiatry, 89(1), 54–64.
Demontis, D., Walters, R. K., Martin, J., Mattheisen, M., Als, T. D., Agerbo, E., Baldursson, G., Belliveau, R., Bybjerg-Grauholm, J., Bækvad-Hansen, M., Cerrato, F., Chambert, K., Churchhouse, C., Dumont, A., Eriksson, N., Gandal, M., Goldstein, J. I., Grasby, K. L., Grove, J., … Neale, B. M. (2019). Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder. Nature Genetics, 51(1), 63–75.
Kimura, R., Swarup, V., Tomiwa, K., Gandal, M. J., Parikshak, N. N., Funabiki, Y., Nakata, M., Awaya, T., Kato, T., Iida, K., Okazaki, S., Matsushima, K., Kato, T., Murai, T., Heike, T., Geschwind, D. H., & Hagiwara, M. (2019). Integrative network analysis reveals biological pathways associated with Williams syndrome. Journal of Child Psychology and Psychiatry, 60(5), 585–598.
Lee, C., Kang, E. Y., Gandal, M. J., Eskin, E., & Geschwind, D. H. (2019). Profiling allele-specific gene expression in brains from individuals with autism spectrum disorder reveals preferential minor allele usage. Nature Neuroscience, 22(9), 1521–1532.
Lopez Soto, E. J., Gandal, M. J., Gonatopoulos-Pournatzis, T., Heller, E. A., Luo, D., & Zheng, S. (2019). Mechanisms of Neuronal Alternative Splicing and Strategies for Therapeutic Interventions. The Journal of Neuroscience, 39(42), 8193–8199.
Ruzzo, E. K., Pérez-Cano, L., Jung, J.-Y., Wang, L.-K., Kashef-Haghighi, D., Hartl, C., Singh, C., Xu, J., Hoekstra, J. N., Leventhal, O., Leppä, V. M., Gandal, M. J., Paskov, K., Stockham, N., Polioudakis, D., Lowe, J. K., Prober, D. A., Geschwind, D. H., & Wall, D. P. (2019). Inherited and De Novo Genetic Risk for Autism Impacts Shared Networks. Cell, 178(4), 850–866.e26.
Schork, A. J., Won, H., Appadurai, V., Nudel, R., Gandal, M., Delaneau, O., Revsbech Christiansen, M., Hougaard, D. M., Bækved-Hansen, M., Bybjerg-Grauholm, J., Giørtz Pedersen, M., Agerbo, E., Bøcker Pedersen, C., Neale, B. M., Daly, M. J., Wray, N. R., Nordentoft, M., Mors, O., Børglum, A. D., … Werge, T. (2019). A genome-wide association study of shared risk across psychiatric disorders implicates gene regulation during fetal neurodevelopment. Nature Neuroscience, 22(3), 353–361.
Walker, R. L., Ramaswami, G., Hartl, C., Mancuso, N., Gandal, M. J., de la Torre-Ubieta, L., Pasaniuc, B., Stein, J. L., & Geschwind, D. H. (2019). Genetic Control of Expression and Splicing in Developing Human Brain Informs Disease Mechanisms. Cell, 179(3), 750–771.e22.
Fan, C. C., McGrath, J. J., Appadurai, V., Buil, A., Gandal, M. J., Schork, A. J., Mortensen, P. B., Agerbo, E., Geschwind, S. A., Geschwind, D., Werge, T., Thompson, W. K., & Pedersen, C. B. (2018). Spatial fine-mapping for gene-by-environment effects identifies risk hot spots for schizophrenia. Nature Communications, 9(1), 5296.
Gandal, M. J., Haney, J. R., Parikshak, N. N., Leppa, V., Ramaswami, G., Hartl, C., Schork, A. J., Appadurai, V., Buil, A., Werge, T. M., Liu, C., White, K. P., CommonMind Consortium, PsychENCODE Consortium, iPSYCH-BROAD Working Group, Horvath, S., & Geschwind, D. H. (2018). Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap. Science, 359(6376), 693–697.
Gandal, M. J., Zhang, P., Hadjimichael, E., Walker, R. L., Chen, C., Liu, S., Won, H., van Bakel, H., Varghese, M., Wang, Y., Shieh, A. W., Haney, J., Parhami, S., Belmont, J., Kim, M., Moran Losada, P., Khan, Z., Mleczko, J., Xia, Y., … Geschwind, D. H. (2018). Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder. Science, 362(6420).
Haney, J. R., Parhami, S., & Gandal, M. J. (2018). Banking on Polygenicity to Disentangle Psychiatric Comorbidity Biological Psychiatry. Cognitive Neuroscience and Neuroimaging, 3(7), 577–578.
Schwede, M., Nagpal, S., Gandal, M. J., Parikshak, N. N., Mirnics, K., Geschwind, D. H., & Morrow, E. M. (2018). Strong correlation of downregulated genes related to synaptic transmission and mitochondria in post-mortem autism cerebral cortex. Journal of Neurodevelopmental Disorders, 10(1), 18.
Wang, D., Liu, S., Warrell, J., Won, H., Shi, X., Navarro, F. C. P., Clarke, D., Gu, M., Emani, P., Yang, Y. T., Xu, M., Gandal, M. J., Lou, S., Zhang, J., Park, J. J., Yan, C., Rhie, S. K., Manakongtreecheep, K., Zhou, H., … Gerstein, M. B. (2018). Comprehensive functional genomic resource and integrative model for the human brain. Science, 362(6420).
Singh, T., Walters, J. T. R., Johnstone, M., Curtis, D., Suvisaari, J., Torniainen, M., Rees, E., Iyegbe, C., Blackwood, D., McIntosh, A. M., Kirov, G., Geschwind, D., Murray, R. M., Di Forti, M., Bramon, E., Gandal, M., Hultman, C. M., Sklar, P., INTERVAL Study, … Barrett. (2017). The contribution of rare variants to risk of schizophrenia in individuals with and without intellectual disability. Nature Genetics, 49(8), 1167–1173.
Gandal, M. J., & Geschwind, D. H. (2016). The Genetics-Driven Revival in Neuropsychiatric Drug Development. Biological Psychiatry, 79(8), 628–630.
Gandal, M. J., Leppa, V., Won, H., Parikshak, N. N., & Geschwind, D. H. (2016). The road to precision psychiatry: translating genetics into disease mechanisms. Nature Neuroscience, 19(11), 1397–1407.
Parikshak, N. N., Swarup, V., Belgard, T. G., Irimia, M., Ramaswami, G., Gandal, M. J., Hartl, C., Leppa, V., Ubieta, L. de la T., Huang, J., Lowe, J. K., Blencowe, B. J., Horvath, S., & Geschwind, D. H. (2016). Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism. Nature, 540(7633), 423–427.
Pierre, J. M., Gandal, M., & Son, M. (2016). Cannabis-induced psychosis associated with high potency “wax dabs.” Schizophrenia Research, 172(1-3), 211–212.
Won, H., de la Torre-Ubieta, L., Stein, J. L., Parikshak, N. N., Huang, J., Opland, C. K., Gandal, M. J., Sutton, G. J., Hormozdiari, F., Lu, D., Lee, C., Eskin, E., Voineagu, I., Ernst, J., & Geschwind, D. H. (2016). Chromosome conformation elucidates regulatory relationships in developing human brain. Nature, 538(7626), 523–527.
